Endocrine Abstracts

Excessive expression of CyD1 in CCND1 gene increase G1-S phase transition and cellular proliferation. In various tumor types and of the few studies of pituitary adenomas, over expression of CyD1 or amplification in the locus of CCND1 gene, have been demonstrated. In this study, we aimed to investigate the effect of cyclin D1 gene polymorphism on tumor formation in prolactinoma patients.A hundred and thirteen patients and 108 age and gender matched contro...

Introduction: Prolactinomas, although considered benign, show various intensity of aggressiveness. Some remain constant for whole life period while some harbour initially with invasive extension to the parasellar area. We aimed to evaluate the effect of age and gender on the invasiveness of prolactinomas.Material-methods: One hundred and thirteen patients with prolactinoma were retrospectively evaluated. Magnetic resonance images were carefully examined ...

Introduction: Fine-needle aspiration (FNA) biopsy of thyroid nodules is minimally invasive and safe. The clinical importance of the thyroid nodule evaluation is primarily related to the need to exclude thyroid cancer. We aimed to investigate the relationship between preoperative FNA cytology and results of thyroidectomy in this study.Materials and Methods: Histopathologic examination reports of 302 patients undergoing thyroidectomy and preoperative FNA c...

Introduction: Women with polycystic ovary syndrome (PCOS) have an increased prevalence of insulin resistance and related disorders. Endothelial dysfunction and chronic inflammation are early findings in the atherosclerotic process. Elevated serum levels of uric acid may reflect low-grade chronic inflammation. But there are controversial data whether increased the uric acid level in PCOS patients. This study was aimed to examine the relationship between uric acid, lipoprotein l...

In prolactin secreting pituitary adenomas, surgery markedly reduced with the efficacy of dopamine agonists in controlling prolactin hypersecretion and reducing tumor mass. Some surgeons, instead of necessity of almost life-long medical therapy, prefer and recommend surgery as a first line treatment with potentially high success rates especially in microprolactinomas. We evaluated our patients with prolactinoma operated mostly without any evidence of resistance or intolerance t...